Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.
نویسندگان
چکیده
The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.
منابع مشابه
Exploiting C3-symmetry in the dynamic coordination of a chiral trisoxazoline to copper(II): improved enantioselectivity, and catalyst stability in asymmetric lewis acid catalysis.
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 133 35 شماره
صفحات -
تاریخ انتشار 2011